Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 5.123


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ELK4chr1_-_2038674020.712.1e-03Click!
GABPAchr21_+_260295420.665.4e-03Click!
GABPB1chr15_-_484348960.421.1e-01Click!
ELK1chrX_-_47394808-0.283.0e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_49008445 10.909 NM_003859
 DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr2_-_152740387 9.503 NM_005843
 STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr20_+_21231921 7.471 NM_012255
 XRN2
5'-3' exoribonuclease 2
chr20_+_49008754 6.732 NM_014484
 MOCS3
molybdenum cofactor synthesis 3
chr20_+_60395515 6.645 NM_001024
 RPS21
ribosomal protein S21
chr6_+_111409933 6.459 NM_032194
 RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr2_-_27147995 6.179 NM_001134693
 OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr2_-_73817935 6.063 NM_016058
 TPRKB
TP53RK binding protein
chr12_+_118590039 6.006 NM_006253
 PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr2_+_220170804 5.607 NM_052902
 STK11IP
serine/threonine kinase 11 interacting protein
chr1_-_28842103 5.428 NM_001135218
NM_005644
 TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr17_-_53784494 5.343 NM_003168
 SUPT4H1
suppressor of Ty 4 homolog 1 (S. cerevisiae)
chr2_-_201461945 5.308 NM_032472
NM_130906
 PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr6_+_30693464 5.298 NM_014046
 MRPS18B
mitochondrial ribosomal protein S18B
chr2_+_176842368 5.225 NM_006554
 MTX2
metaxin 2
chr2_-_20413838 5.112 PUM2
pumilio homolog 2 (Drosophila)
chr3_-_130600931 5.075 RPL32P3
ribosomal protein L32 pseudogene 3
chr2_+_32244406 5.008 NM_001193513
NM_001193514
NM_001193515
NM_017964
 SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr2_-_54051290 5.002 NM_014614
 PSME4
proteasome (prosome, macropain) activator subunit 4
chr6_-_119137923 4.902 NM_001178035
 C6orf204
chromosome 6 open reading frame 204

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 172 entries
enrichment   p-value GO term description
2.39 3.62e-07 GO:0006415 translational termination
2.38 1.23e-06 GO:0019080 viral genome expression
2.38 1.23e-06 GO:0019083 viral transcription
2.30 3.24e-07 GO:0006414 translational elongation
2.30 1.64e-05 GO:0022618 ribonucleoprotein complex assembly
2.28 9.91e-04 GO:0071158 positive regulation of cell cycle arrest
2.27 1.36e-05 GO:0071826 ribonucleoprotein complex subunit organization
2.27 4.96e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.26 1.25e-04 GO:0006354 transcription elongation, DNA-dependent
2.26 1.76e-04 GO:0006353 transcription termination, DNA-dependent
2.25 3.23e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.25 3.23e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
2.25 3.23e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.25 3.23e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.25 3.23e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.25 3.23e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
2.25 3.23e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.25 3.23e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.24 1.14e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.22 7.35e-03 GO:0006368 transcription elongation from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 58 entries
enrichment   p-value GO term description
2.49 2.37e-02 GO:0030532 small nuclear ribonucleoprotein complex
2.46 8.02e-06 GO:0015934 large ribosomal subunit
2.44 9.39e-08 GO:0071013 catalytic step 2 spliceosome
2.43 8.62e-03 GO:0022625 cytosolic large ribosomal subunit
2.35 2.74e-12 GO:0005681 spliceosomal complex
2.26 2.97e-05 GO:0022626 cytosolic ribosome
2.10 1.90e-02 GO:0030176 integral to endoplasmic reticulum membrane
2.08 7.02e-03 GO:0044450 microtubule organizing center part
2.06 1.41e-10 GO:0005840 ribosome
2.01 3.30e-28 GO:0030529 ribonucleoprotein complex
2.00 8.76e-06 GO:0016607 nuclear speck
1.97 4.41e-02 GO:0000502 proteasome complex
1.94 1.60e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
1.91 1.85e-05 GO:0000151 ubiquitin ligase complex
1.89 5.69e-09 GO:0016604 nuclear body
1.78 3.72e-04 GO:0044445 cytosolic part
1.75 2.47e-03 GO:0000793 condensed chromosome
1.68 8.86e-04 GO:0005819 spindle
1.64 9.45e-11 GO:0005730 nucleolus
1.59 2.75e-02 GO:0044454 nuclear chromosome part

Gene overrepresentation in function category:

Showing 1 to 20 of 37 entries
enrichment   p-value GO term description
2.03 1.63e-07 GO:0003735 structural constituent of ribosome
1.91 2.54e-02 GO:0008135 translation factor activity, nucleic acid binding
1.80 9.84e-07 GO:0004842 ubiquitin-protein ligase activity
1.80 2.09e-02 GO:0008026 ATP-dependent helicase activity
1.80 2.09e-02 GO:0070035 purine NTP-dependent helicase activity
1.77 1.11e-06 GO:0019787 small conjugating protein ligase activity
1.71 1.23e-02 GO:0004386 helicase activity
1.62 1.13e-04 GO:0016881 acid-amino acid ligase activity
1.61 4.48e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.59 4.74e-02 GO:0008168 methyltransferase activity
1.55 1.22e-13 GO:0003723 RNA binding
1.51 4.61e-02 GO:0003713 transcription coactivator activity
1.49 1.38e-02 GO:0042623 ATPase activity, coupled
1.43 2.04e-02 GO:0016887 ATPase activity
1.42 1.49e-02 GO:0003712 transcription cofactor activity
1.41 1.71e-02 GO:0000988 protein binding transcription factor activity
1.41 1.71e-02 GO:0000989 transcription factor binding transcription factor activity
1.40 5.04e-03 GO:0016874 ligase activity
1.38 3.73e-05 GO:0019899 enzyme binding
1.30 5.27e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides