Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 5.123


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ELK4chr1_-_2038674020.712.1e-03Click!
GABPAchr21_+_260295420.665.4e-03Click!
GABPB1chr15_-_484348960.421.1e-01Click!
ELK1chrX_-_47394808-0.283.0e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_49008445 10.909 NM_003859
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr2_-_152740387 9.503 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr20_+_21231921 7.471 NM_012255
XRN2
5'-3' exoribonuclease 2
chr20_+_49008754 6.732 NM_014484
MOCS3
molybdenum cofactor synthesis 3
chr20_+_60395515 6.645 NM_001024
RPS21
ribosomal protein S21
chr6_+_111409933 6.459 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr2_-_27147995 6.179 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr2_-_73817935 6.063 NM_016058
TPRKB
TP53RK binding protein
chr12_+_118590039 6.006 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr2_+_220170804 5.607 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr1_-_28842103 5.428 NM_001135218
NM_005644
TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr17_-_53784494 5.343 NM_003168
SUPT4H1
suppressor of Ty 4 homolog 1 (S. cerevisiae)
chr2_-_201461945 5.308 NM_032472
NM_130906
PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr6_+_30693464 5.298 NM_014046
MRPS18B
mitochondrial ribosomal protein S18B
chr2_+_176842368 5.225 NM_006554
MTX2
metaxin 2
chr2_-_20413838 5.112 PUM2
pumilio homolog 2 (Drosophila)
chr3_-_130600931 5.075 RPL32P3
ribosomal protein L32 pseudogene 3
chr2_+_32244406 5.008 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr2_-_54051290 5.002 NM_014614
PSME4
proteasome (prosome, macropain) activator subunit 4
chr6_-_119137923 4.902 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr1_+_232575850 4.896 NM_001012985
C1orf31
chromosome 1 open reading frame 31
chr14_-_23781607 4.807 NM_001099274
NM_012461
TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr16_-_11852862 4.786 NM_015659
RSL1D1
ribosomal L1 domain containing 1
chr11_-_17055763 4.774 NM_001017
RPS13
ribosomal protein S13
chr17_-_53282376 4.764 NM_016070
MRPS23
mitochondrial ribosomal protein S23
chr21_-_29286982 4.738 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr12_-_48248132 4.693 NM_006337
MCRS1
microspherule protein 1
chr14_-_23781328 4.684 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr4_-_4300821 4.681 NM_032927
TMEM128
transmembrane protein 128
chr17_-_44377094 4.629 NM_007241
SNF8
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
chr20_+_60395623 4.605 RPS21
ribosomal protein S21
chr17_-_53950191 4.578 NM_004687
MTMR4
myotubularin related protein 4
chr16_+_21926939 4.551 NM_001164579
C16orf52
chromosome 16 open reading frame 52
chr2_+_201462294 4.545 NM_001136039
NM_001142355
NM_021824
NIF3L1


NIF3 NGG1 interacting factor 3-like 1 (S. pombe)


chr20_-_5041482 4.528 NM_001009923
NM_001009924
NM_001009925
NM_014145
C20orf30



chromosome 20 open reading frame 30



chr15_+_32304477 4.527 NM_016454
TMEM85
transmembrane protein 85
chr1_+_22224571 4.521 HSPC157
hypothetical LOC29092
chr7_+_107171809 4.481 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr12_-_119116848 4.479 NM_006836
GCN1L1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr20_-_44426407 4.467 NM_015945
NM_173073
NM_173179
SLC35C2


solute carrier family 35, member C2


chr20_+_18496068 4.437 LOC388789
hypothetical LOC388789
chr2_+_97628929 4.416 NM_001862
COX5B
cytochrome c oxidase subunit Vb
chr12_-_104153920 4.375 NM_018171
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr14_+_34521945 4.370 SRP54
signal recognition particle 54kDa
chr6_+_170705345 4.271 NM_001172085
NM_003194
TBP

TATA box binding protein

chr20_+_43478120 4.261 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr16_+_68938264 4.257 NM_018332
DDX19A
DEAD (Asp-Glu-Ala-As) box polypeptide 19A
chr14_-_38709161 4.249 NM_001079537
NM_177452
TRAPPC6B

trafficking protein particle complex 6B

chr10_-_15942461 4.189 NM_024948
FAM188A
family with sequence similarity 188, member A
chr20_-_2592777 4.181 NM_006899
NM_174855
NM_174856
IDH3B


isocitrate dehydrogenase 3 (NAD+) beta


chr20_+_3138055 4.126 NM_033453
NM_181493
ITPA

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

chr14_+_34521854 4.113 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr6_-_28327980 4.089 NM_019110
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr21_+_42807052 4.061 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr7_-_44496703 4.057 NM_015332
NUDCD3
NudC domain containing 3
chr20_+_33750645 4.044 NM_080748
ROMO1
reactive oxygen species modulator 1
chr16_+_79132354 3.994 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr14_+_73423260 3.980 NM_021188
ZNF410
zinc finger protein 410
chr6_+_10803141 3.978 NM_017906
PAK1IP1
PAK1 interacting protein 1
chr14_+_23937766 3.971 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_-_122210873 3.901 NM_032390
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein
chr16_-_3601580 3.856 NM_032444
SLX4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr16_-_15095590 3.811 NM_018427
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr17_-_38229790 3.775 NM_003766
BECN1
beclin 1, autophagy related
chr14_+_23771464 3.774 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr2_+_128565269 3.769 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr16_+_8799170 3.765 NM_000303
PMM2
phosphomannomutase 2
chr17_-_59923547 3.745 NM_007215
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr20_+_28225511 3.736 LOC283788
FRG1B
FSHD region gene 1 pseudogene
FSHD region gene 1 family, member B
chr3_+_180348818 3.723 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr17_+_43328514 3.719 NM_003110
SP2
Sp2 transcription factor
chr15_+_72620570 3.680 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr1_-_220829704 3.672 NM_005681
NM_139352
TAF1A

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

chr10_+_112247614 3.657 NM_004419
DUSP5
dual specificity phosphatase 5
chr2_+_69974581 3.625 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr16_+_2593351 3.611 LOC652276
hypothetical LOC652276
chr2_+_65308332 3.609 NM_001005386
NM_005722
ACTR2

ARP2 actin-related protein 2 homolog (yeast)

chr2_+_198026470 3.601 NM_025147
COQ10B
coenzyme Q10 homolog B (S. cerevisiae)
chr6_+_30142910 3.585 NM_021959
PPP1R11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr2_-_68332985 3.582 NM_000945
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr20_-_33750457 3.569 NM_001198989
NM_021100
NFS1

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

chr17_+_72596349 3.556 SEC14L1
C17orf86
SEC14-like 1 (S. cerevisiae)
chromosome 17 open reading frame 86
chr6_-_33398656 3.547 NM_001141969
NM_001141970
NM_001350
DAXX


death-domain associated protein


chr2_-_24995402 3.527 NM_004036
ADCY3
adenylate cyclase 3
chr1_-_234834410 3.524 NM_018072
HEATR1
HEAT repeat containing 1
chr5_-_114626422 3.521 NM_005023
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr12_+_67366989 3.509 NM_020401
NUP107
nucleoporin 107kDa
chr2_-_74915722 3.507


chr6_+_33530297 3.498 NM_152735
ZBTB9
zinc finger and BTB domain containing 9
chr16_+_23560187 3.455 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr16_+_24648446 3.437 NM_014494
TNRC6A
trinucleotide repeat containing 6A
chr6_-_170735593 3.435 NM_002598
NM_144781
PDCD2

programmed cell death 2

chr3_-_130362563 3.432 NM_020701
ISY1
ISY1 splicing factor homolog (S. cerevisiae)
chr2_-_190336168 3.419 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr6_+_139136349 3.377 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr11_-_117628211 3.362 NM_198275
MPZL3
myelin protein zero-like 3
chr7_+_102775309 3.332 NM_002803
PSMC2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
chr2_-_45691887 3.329 NM_018079
SRBD1
S1 RNA binding domain 1
chr3_-_172660545 3.267 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr11_-_57054756 3.260 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr14_-_22127902 3.259 DAD1
defender against cell death 1
chr13_-_36531568 3.248 NM_001014286
NM_017569
FAM48A

family with sequence similarity 48, member A

chr4_+_109761170 3.223 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr16_-_23559978 3.215 NM_024675
PALB2
partner and localizer of BRCA2
chr2_-_175741096 3.208 NM_001880
ATF2
activating transcription factor 2
chr2_-_241690365 3.189 NM_182501
MTERFD2
MTERF domain containing 2
chr13_+_52124831 3.171 NM_001130912
NM_006704
SUGT1

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)

chr20_+_16658608 3.160 NM_003092
NM_198220
SNRPB2

small nuclear ribonucleoprotein polypeptide B

chr16_-_8798973 3.136 NM_015421
TMEM186
transmembrane protein 186
chr17_+_70520339 3.129 NM_001545
ICT1
immature colon carcinoma transcript 1
chr8_-_22582526 3.124 NM_018688
BIN3
bridging integrator 3
chr7_+_104959767 3.117 NM_021930
RINT1
RAD50 interactor 1
chr2_-_65308220 3.110 LOC729324
hCG1986447
chr7_+_50318801 3.099 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr7_-_91713044 3.094 NM_004912
NM_001013406
NM_194454
KRIT1


KRIT1, ankyrin repeat containing


chr1_+_220884257 3.085 MIA3
melanoma inhibitory activity family, member 3
chr17_-_39447817 3.084 NM_032376
TMEM101
transmembrane protein 101
chr2_-_20053256 3.037 NM_001006657
NM_020779
WDR35

WD repeat domain 35

chr1_+_109036431 3.036 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr2_-_131567458 3.008 NM_001009993
FAM168B
family with sequence similarity 168, member B
chr12_+_49080858 2.964 NM_001170803
NM_001170804
NM_001170808
NM_052879
NM_199188
NM_199190
LARP4





La ribonucleoprotein domain family, member 4





chr1_+_23990228 2.955 NM_007260
LYPLA2
lysophospholipase II
chr1_-_3702908 2.953 NM_020710
LRRC47
leucine rich repeat containing 47
chr12_+_122652572 2.952 NM_020936
DDX55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr14_-_21049204 2.935 NM_019852
METTL3
methyltransferase like 3
chr21_+_36614347 2.931 NM_015358
MORC3
MORC family CW-type zinc finger 3
chr3_+_180548173 2.913 NM_033540
MFN1
mitofusin 1
chr20_-_472335 2.908 NM_001895
NM_177559
NM_177560
CSNK2A1


casein kinase 2, alpha 1 polypeptide


chr14_+_23771942 2.902 NM_001002002
NM_016576
GMPR2

guanosine monophosphate reductase 2

chr20_+_61760084 2.899 NM_016434
NM_032957
RTEL1

regulator of telomere elongation helicase 1

chr4_+_110956360 2.892 GAR1
GAR1 ribonucleoprotein homolog (yeast)
chr9_-_124733599 2.886 NM_020924
ZBTB26
zinc finger and BTB domain containing 26
chr3_+_44571600 2.876 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr20_+_42537927 2.874 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr7_+_6583560 2.871 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr2_+_74535700 2.859 NM_031288
INO80B
INO80 complex subunit B
chr10_-_51293220 2.859 NM_006327
TIMM23
TIMM23B
translocase of inner mitochondrial membrane 23 homolog (yeast)
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr1_-_53458822 2.854 NM_017887
C1orf123
chromosome 1 open reading frame 123
chr16_-_79668304 2.852 NM_001100873
NM_152337
C16orf46

chromosome 16 open reading frame 46

chr14_-_38971370 2.851 NM_203301
FBXO33
F-box protein 33
chr2_+_48395271 2.826 NM_002158
FOXN2
forkhead box N2
chr1_+_39229474 2.825 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr3_+_144203061 2.823 NM_001080415
U2SURP
U2 snRNP-associated SURP domain containing
chr10_-_51041156 2.809 NM_003631
AGAP8
LOC728407
PARG
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
poly(ADP-ribose) glycohydrolase pseudogene
poly (ADP-ribose) glycohydrolase
chr5_+_69381105 2.799 NM_000344
NM_022874
NM_017411
NM_022875
NM_022876
NM_022877
SMN1

SMN2



survival of motor neuron 1, telomeric

survival of motor neuron 2, centromeric



chr12_-_47698781 2.789 NM_002733
NM_212461
PRKAG1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

chr12_+_56424930 2.763 NM_005981
TSPAN31
tetraspanin 31
chr2_+_118562499 2.763 NM_016133
INSIG2
insulin induced gene 2
chr3_+_32701663 2.753 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr2_+_239000395 2.740 ASB1
ankyrin repeat and SOCS box containing 1
chr6_-_10802823 2.735 NM_001145020
C6orf52
chromosome 6 open reading frame 52
chr11_-_13441294 2.723 NM_032320
BTBD10
BTB (POZ) domain containing 10
chr11_-_71501385 2.721 NM_014042
C11orf51
chromosome 11 open reading frame 51
chr16_-_70400232 2.717 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr20_-_57040700 2.704 NM_006886
NM_001001977
ATP5E

ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit

chr10_-_18980512 2.699 NM_182543
NSUN6
NOP2/Sun domain family, member 6
chr4_+_56509793 2.697 NM_025009
CEP135
centrosomal protein 135kDa
chr7_+_39572396 2.690 NM_020192
C7orf36
chromosome 7 open reading frame 36
chr4_-_13238368 2.690 NM_148894
BOD1L
biorientation of chromosomes in cell division 1-like
chr5_-_159778621 2.682 NM_006425
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr9_+_36562844 2.682 NM_014791
MELK
maternal embryonic leucine zipper kinase
chr17_+_35629080 2.677 NM_133264
WIPF2
WAS/WASL interacting protein family, member 2
chr5_+_74098828 2.670 NM_014886
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr17_-_74990157 2.669 NM_001082575
RBFOX3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr7_-_32496497 2.656 NM_012322
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_+_229731021 2.656 NM_005999
TSNAX-DISC1
TSNAX
TSNAX-DISC1 read-through gene
translin-associated factor X
chr1_+_45926433 2.645 NM_016486
TMEM69
transmembrane protein 69
chr15_+_63948823 2.623 NM_004663
RAB11A
RAB11A, member RAS oncogene family
chr2_+_113058642 2.597 CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr1_-_32888677 2.587 NM_178547
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr2_+_3362449 2.586 NM_016030
TTC15
tetratricopeptide repeat domain 15
chr15_+_48503860 2.586 NM_001128610
NM_001128611
NM_005154
USP8


ubiquitin specific peptidase 8


chr9_-_133141726 2.584 NM_033387
FAM78A
family with sequence similarity 78, member A
chr2_+_100985122 2.569 NM_000993
NM_001098577
NM_001099693
RPL31


ribosomal protein L31


chr8_-_120914233 2.562 NM_003184
TAF2
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
chr2_+_27740254 2.558 SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr11_+_8660913 2.543 RPL27A
ribosomal protein L27a
chr1_+_172104115 2.526 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr6_+_41714171 2.524 NM_005586
MDFI
MyoD family inhibitor
chr1_-_38228179 2.518 NM_006802
SF3A3
splicing factor 3a, subunit 3, 60kDa
chr8_+_11179724 2.517 MTMR9
myotubularin related protein 9
chr2_-_240724373 2.514 NM_001163424
NM_138336
MYEOV2

myeloma overexpressed 2

chr2_+_122124034 2.488 LOC254128
hypothetical LOC254128
chr4_-_84595967 2.468 NM_133636
HELQ
helicase, POLQ-like
chr14_+_22368942 2.466 MRPL52
mitochondrial ribosomal protein L52
chr1_+_212520899 2.460 NM_020197
SMYD2
SET and MYND domain containing 2
chr14_-_22127954 2.460 NM_001344
DAD1
defender against cell death 1
chr14_+_20527971 2.455 METTL17
methyltransferase like 17
chr16_-_82778071 2.452 NM_005679
NM_139353
TAF1C

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

chr2_-_197883569 2.450 ANKRD44
ankyrin repeat domain 44
chr20_-_5879036 2.446 NM_015939
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr17_-_975809 2.446 ABR
active BCR-related gene
chr16_+_2672527 2.445 KCTD5
potassium channel tetramerisation domain containing 5
chr2_+_128565222 2.443 NM_020120
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_+_32034559 2.438 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr4_+_84596141 2.434 NM_016067
MRPS18C
mitochondrial ribosomal protein S18C
chr11_+_61647990 2.434 NM_001040694
NM_020238
INCENP

inner centromere protein antigens 135/155kDa

chr20_-_31452991 2.432 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr2_-_27739947 2.414 NM_014860
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr12_-_64810768 2.410 NM_032338
LLPH
LLP homolog, long-term synaptic facilitation (Aplysia)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 2.92e-49 GO:0044260 cellular macromolecule metabolic process
1.32 9.03e-37 GO:0043170 macromolecule metabolic process
1.26 1.82e-35 GO:0044237 cellular metabolic process
1.44 3.37e-32 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 1.96e-31 GO:0090304 nucleic acid metabolic process
1.49 4.57e-25 GO:0010467 gene expression
1.51 1.26e-24 GO:0016070 RNA metabolic process
1.20 1.55e-24 GO:0008152 metabolic process
1.40 4.45e-24 GO:0044267 cellular protein metabolic process
1.21 7.60e-23 GO:0044238 primary metabolic process
1.34 7.97e-23 GO:0034641 cellular nitrogen compound metabolic process
1.32 5.98e-21 GO:0006807 nitrogen compound metabolic process
1.46 2.55e-19 GO:0009059 macromolecule biosynthetic process
1.46 8.07e-19 GO:0034645 cellular macromolecule biosynthetic process
1.33 1.96e-17 GO:0071841 cellular component organization or biogenesis at cellular level
1.92 7.48e-17 GO:0016032 viral reproduction
1.80 8.08e-17 GO:0016071 mRNA metabolic process
1.70 1.50e-15 GO:0006396 RNA processing
1.27 1.58e-15 GO:0071840 cellular component organization or biogenesis
1.42 1.65e-15 GO:0006996 organelle organization
1.53 1.15e-14 GO:0007049 cell cycle
1.72 1.64e-14 GO:0000278 mitotic cell cycle
2.00 2.10e-14 GO:0008380 RNA splicing
1.31 4.10e-14 GO:0071842 cellular component organization at cellular level
1.28 7.48e-14 GO:0019538 protein metabolic process
1.31 5.64e-13 GO:0044249 cellular biosynthetic process
1.30 6.86e-13 GO:0009058 biosynthetic process
1.25 1.36e-12 GO:0016043 cellular component organization
1.09 1.70e-12 GO:0009987 cellular process
1.82 2.45e-12 GO:0006397 mRNA processing
1.71 3.06e-12 GO:0006974 response to DNA damage stimulus
1.63 1.22e-11 GO:0009057 macromolecule catabolic process
1.58 4.82e-11 GO:0022403 cell cycle phase
1.53 5.25e-11 GO:0022402 cell cycle process
1.87 7.31e-11 GO:0006412 translation
2.07 7.45e-11 GO:0071843 cellular component biogenesis at cellular level
1.66 9.33e-11 GO:0044265 cellular macromolecule catabolic process
2.09 1.33e-10 GO:0022613 ribonucleoprotein complex biogenesis
1.86 1.97e-10 GO:0051329 interphase of mitotic cell cycle
1.85 3.56e-10 GO:0051325 interphase
2.03 9.52e-10 GO:0000375 RNA splicing, via transesterification reactions
1.80 9.92e-10 GO:0051603 proteolysis involved in cellular protein catabolic process
2.04 1.29e-09 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.04 1.29e-09 GO:0000398 nuclear mRNA splicing, via spliceosome
1.78 2.22e-09 GO:0044257 cellular protein catabolic process
1.48 2.94e-09 GO:0033554 cellular response to stress
1.74 4.94e-09 GO:0030163 protein catabolic process
1.56 6.15e-09 GO:0051726 regulation of cell cycle
1.78 6.27e-09 GO:0043632 modification-dependent macromolecule catabolic process
1.49 6.91e-09 GO:0046907 intracellular transport
1.76 7.24e-09 GO:0070647 protein modification by small protein conjugation or removal
1.78 8.62e-09 GO:0019941 modification-dependent protein catabolic process
1.79 9.35e-09 GO:0006511 ubiquitin-dependent protein catabolic process
1.41 9.56e-09 GO:0008104 protein localization
1.46 1.26e-08 GO:0015031 protein transport
1.43 1.77e-08 GO:0032774 RNA biosynthetic process
1.45 2.14e-08 GO:0045184 establishment of protein localization
1.38 3.57e-08 GO:0044248 cellular catabolic process
1.81 8.95e-08 GO:0007346 regulation of mitotic cell cycle
1.70 1.60e-07 GO:0010564 regulation of cell cycle process
1.77 2.65e-07 GO:0032446 protein modification by small protein conjugation
1.28 2.70e-07 GO:0006464 protein modification process
2.30 3.24e-07 GO:0006414 translational elongation
1.74 3.26e-07 GO:0048285 organelle fission
1.80 3.35e-07 GO:0016567 protein ubiquitination
2.39 3.62e-07 GO:0006415 translational termination
1.34 3.63e-07 GO:0033036 macromolecule localization
1.57 3.76e-07 GO:0034621 cellular macromolecular complex subunit organization
1.27 4.34e-07 GO:0043412 macromolecule modification
2.38 1.23e-06 GO:0019080 viral genome expression
2.38 1.23e-06 GO:0019083 viral transcription
1.82 2.12e-06 GO:0071156 regulation of cell cycle arrest
1.83 3.11e-06 GO:0000075 cell cycle checkpoint
1.95 5.30e-06 GO:0010498 proteasomal protein catabolic process
1.95 5.30e-06 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.30 5.96e-06 GO:0009056 catabolic process
1.68 6.30e-06 GO:0000087 M phase of mitotic cell cycle
1.32 6.47e-06 GO:0051641 cellular localization
2.21 8.89e-06 GO:0043241 protein complex disassembly
2.21 8.89e-06 GO:0043624 cellular protein complex disassembly
1.39 1.03e-05 GO:0008219 cell death
2.12 1.30e-05 GO:0032984 macromolecular complex disassembly
2.12 1.30e-05 GO:0034623 cellular macromolecular complex disassembly
2.27 1.36e-05 GO:0071826 ribonucleoprotein complex subunit organization
1.39 1.44e-05 GO:0043933 macromolecular complex subunit organization
2.30 1.64e-05 GO:0022618 ribonucleoprotein complex assembly
1.38 1.76e-05 GO:0016265 death
1.67 2.08e-05 GO:0000280 nuclear division
1.67 2.08e-05 GO:0007067 mitosis
1.50 2.15e-05 GO:0070727 cellular macromolecule localization
1.98 2.74e-05 GO:0019058 viral infectious cycle
1.42 3.42e-05 GO:0006915 apoptosis
1.89 3.95e-05 GO:0022415 viral reproductive process
1.49 4.22e-05 GO:0034613 cellular protein localization
2.00 5.19e-05 GO:0042254 ribosome biogenesis
1.45 5.54e-05 GO:0006259 DNA metabolic process
1.55 6.55e-05 GO:0006886 intracellular protein transport
1.31 6.78e-05 GO:0044085 cellular component biogenesis
1.60 7.01e-05 GO:0006281 DNA repair
1.32 7.98e-05 GO:0051649 establishment of localization in cell
2.06 8.88e-05 GO:0000077 DNA damage checkpoint
1.97 1.07e-04 GO:0007093 mitotic cell cycle checkpoint
2.26 1.25e-04 GO:0006354 transcription elongation, DNA-dependent
1.39 1.37e-04 GO:0012501 programmed cell death
2.20 1.59e-04 GO:2000045 regulation of G1/S transition of mitotic cell cycle
2.26 1.76e-04 GO:0006353 transcription termination, DNA-dependent
1.92 2.15e-04 GO:0048193 Golgi vesicle transport
2.20 3.19e-04 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.20 3.19e-04 GO:0071779 G1/S transition checkpoint
2.27 4.96e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
1.99 5.69e-04 GO:0000084 S phase of mitotic cell cycle
1.69 6.04e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.16 6.71e-04 GO:0060255 regulation of macromolecule metabolic process
1.36 7.42e-04 GO:0016192 vesicle-mediated transport
2.14 7.77e-04 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
2.28 9.91e-04 GO:0071158 positive regulation of cell cycle arrest
2.24 1.14e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.95 1.15e-03 GO:0051320 S phase
1.48 1.16e-03 GO:0000279 M phase
1.94 1.16e-03 GO:0031570 DNA integrity checkpoint
1.52 1.17e-03 GO:0044419 interspecies interaction between organisms
1.40 1.36e-03 GO:0071822 protein complex subunit organization
1.82 1.92e-03 GO:0000082 G1/S transition of mitotic cell cycle
1.32 1.92e-03 GO:0006351 transcription, DNA-dependent
1.67 2.00e-03 GO:0033365 protein localization to organelle
1.58 2.24e-03 GO:0010608 posttranscriptional regulation of gene expression
2.12 2.39e-03 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.04 2.82e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.73 3.12e-03 GO:0043687 post-translational protein modification
1.89 3.13e-03 GO:0031018 endocrine pancreas development
1.92 3.20e-03 GO:0042770 signal transduction in response to DNA damage
2.25 3.23e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.25 3.23e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
2.25 3.23e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.25 3.23e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.25 3.23e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.25 3.23e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
2.25 3.23e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.25 3.23e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.09 3.61e-03 GO:0000216 M/G1 transition of mitotic cell cycle
1.50 3.91e-03 GO:0051301 cell division
2.00 4.25e-03 GO:0051438 regulation of ubiquitin-protein ligase activity
2.14 4.45e-03 GO:0051352 negative regulation of ligase activity
2.14 4.45e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.49 5.09e-03 GO:0016568 chromatin modification
1.96 6.21e-03 GO:0051340 regulation of ligase activity
2.11 6.80e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.62 7.17e-03 GO:0009261 ribonucleotide catabolic process
2.22 7.35e-03 GO:0006368 transcription elongation from RNA polymerase II promoter
1.77 8.54e-03 GO:0031016 pancreas development
2.03 1.13e-02 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.77 1.22e-02 GO:0007005 mitochondrion organization
1.60 1.68e-02 GO:0009203 ribonucleoside triphosphate catabolic process
1.60 1.68e-02 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.99 1.68e-02 GO:0051351 positive regulation of ligase activity
1.64 1.90e-02 GO:0022411 cellular component disassembly
1.64 1.90e-02 GO:0071845 cellular component disassembly at cellular level
1.59 1.92e-02 GO:0009154 purine ribonucleotide catabolic process
1.27 2.00e-02 GO:0042981 regulation of apoptosis
1.60 2.07e-02 GO:0009146 purine nucleoside triphosphate catabolic process
1.74 2.87e-02 GO:0010565 regulation of cellular ketone metabolic process
1.26 2.92e-02 GO:0043067 regulation of programmed cell death
1.63 2.97e-02 GO:0034470 ncRNA processing
1.34 3.49e-02 GO:0051276 chromosome organization
1.57 3.80e-02 GO:0009143 nucleoside triphosphate catabolic process
1.25 3.98e-02 GO:0010941 regulation of cell death
1.81 4.05e-02 GO:0000086 G2/M transition of mitotic cell cycle
1.26 4.10e-02 GO:0032268 regulation of cellular protein metabolic process
1.62 4.24e-02 GO:0006260 DNA replication
2.18 4.73e-02 GO:0006521 regulation of cellular amino acid metabolic process
1.90 4.76e-02 GO:0006364 rRNA processing
1.15 4.85e-02 GO:0010468 regulation of gene expression

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 5.55e-75 GO:0044424 intracellular part
1.18 2.38e-74 GO:0005622 intracellular
1.22 1.10e-63 GO:0043229 intracellular organelle
1.22 3.08e-63 GO:0043226 organelle
1.24 6.36e-61 GO:0043231 intracellular membrane-bounded organelle
1.24 1.25e-60 GO:0043227 membrane-bounded organelle
1.31 6.01e-43 GO:0005634 nucleus
1.30 2.85e-40 GO:0044446 intracellular organelle part
1.29 9.91e-39 GO:0044422 organelle part
1.52 5.84e-36 GO:0044428 nuclear part
1.19 5.70e-33 GO:0005737 cytoplasm
1.47 9.09e-32 GO:0031974 membrane-enclosed lumen
1.47 4.70e-31 GO:0070013 intracellular organelle lumen
1.46 1.32e-30 GO:0043233 organelle lumen
1.52 1.07e-29 GO:0031981 nuclear lumen
2.01 3.30e-28 GO:0030529 ribonucleoprotein complex
1.22 6.42e-26 GO:0044444 cytoplasmic part
1.29 7.23e-21 GO:0032991 macromolecular complex
1.52 2.88e-20 GO:0005654 nucleoplasm
1.32 4.47e-18 GO:0043228 non-membrane-bounded organelle
1.32 4.47e-18 GO:0043232 intracellular non-membrane-bounded organelle
1.34 1.08e-14 GO:0005829 cytosol
2.35 2.74e-12 GO:0005681 spliceosomal complex
1.64 9.45e-11 GO:0005730 nucleolus
2.06 1.41e-10 GO:0005840 ribosome
1.49 2.30e-09 GO:0044451 nucleoplasm part
1.04 3.12e-09 GO:0044464 cell part
1.04 3.38e-09 GO:0005623 cell
1.89 5.69e-09 GO:0016604 nuclear body
1.21 6.90e-08 GO:0043234 protein complex
2.44 9.39e-08 GO:0071013 catalytic step 2 spliceosome
1.48 2.22e-06 GO:0005694 chromosome
2.46 8.02e-06 GO:0015934 large ribosomal subunit
2.00 8.76e-06 GO:0016607 nuclear speck
1.22 1.08e-05 GO:0031090 organelle membrane
1.91 1.85e-05 GO:0000151 ubiquitin ligase complex
2.26 2.97e-05 GO:0022626 cytosolic ribosome
1.27 4.15e-05 GO:0005739 mitochondrion
1.37 1.02e-04 GO:0031967 organelle envelope
1.36 1.81e-04 GO:0031975 envelope
1.45 1.86e-04 GO:0044427 chromosomal part
1.78 3.72e-04 GO:0044445 cytosolic part
1.68 8.86e-04 GO:0005819 spindle
1.75 2.47e-03 GO:0000793 condensed chromosome
1.45 6.54e-03 GO:0005815 microtubule organizing center
1.34 6.93e-03 GO:0044431 Golgi apparatus part
2.08 7.02e-03 GO:0044450 microtubule organizing center part
1.26 7.79e-03 GO:0005794 Golgi apparatus
2.43 8.62e-03 GO:0022625 cytosolic large ribosomal subunit
1.31 9.98e-03 GO:0015630 microtubule cytoskeleton
1.31 9.98e-03 GO:0044429 mitochondrial part
1.55 1.24e-02 GO:0000228 nuclear chromosome
1.94 1.60e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.10 1.90e-02 GO:0030176 integral to endoplasmic reticulum membrane
2.49 2.37e-02 GO:0030532 small nuclear ribonucleoprotein complex
1.59 2.75e-02 GO:0044454 nuclear chromosome part
1.48 4.15e-02 GO:0005635 nuclear envelope
1.97 4.41e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 9.19e-26 GO:0005515 protein binding
1.09 7.78e-18 GO:0005488 binding
1.27 2.63e-16 GO:0003676 nucleic acid binding
1.55 1.22e-13 GO:0003723 RNA binding
2.03 1.63e-07 GO:0003735 structural constituent of ribosome
1.80 9.84e-07 GO:0004842 ubiquitin-protein ligase activity
1.77 1.11e-06 GO:0019787 small conjugating protein ligase activity
1.38 3.73e-05 GO:0019899 enzyme binding
1.61 4.48e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.62 1.13e-04 GO:0016881 acid-amino acid ligase activity
1.20 1.22e-04 GO:0000166 nucleotide binding
1.11 1.91e-04 GO:0003824 catalytic activity
1.21 5.99e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.20 7.80e-04 GO:0017076 purine nucleotide binding
1.18 8.32e-04 GO:0003677 DNA binding
1.20 1.18e-03 GO:0032553 ribonucleotide binding
1.20 1.18e-03 GO:0032555 purine ribonucleotide binding
1.18 3.62e-03 GO:0008270 zinc ion binding
1.40 5.04e-03 GO:0016874 ligase activity
1.30 5.27e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.30 7.15e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.30 7.83e-03 GO:0017111 nucleoside-triphosphatase activity
1.30 8.36e-03 GO:0016462 pyrophosphatase activity
1.71 1.23e-02 GO:0004386 helicase activity
1.49 1.38e-02 GO:0042623 ATPase activity, coupled
1.42 1.49e-02 GO:0003712 transcription cofactor activity
1.20 1.61e-02 GO:0005524 ATP binding
1.41 1.71e-02 GO:0000988 protein binding transcription factor activity
1.41 1.71e-02 GO:0000989 transcription factor binding transcription factor activity
1.20 1.89e-02 GO:0032559 adenyl ribonucleotide binding
1.20 1.91e-02 GO:0030554 adenyl nucleotide binding
1.43 2.04e-02 GO:0016887 ATPase activity
1.80 2.09e-02 GO:0008026 ATP-dependent helicase activity
1.80 2.09e-02 GO:0070035 purine NTP-dependent helicase activity
1.91 2.54e-02 GO:0008135 translation factor activity, nucleic acid binding
1.51 4.61e-02 GO:0003713 transcription coactivator activity
1.59 4.74e-02 GO:0008168 methyltransferase activity